Felty Syndrome is a rare autoimmune disorder, primarily associated with chronic rheumatoid arthritis (RA). It is characterized by RA, an enlarged spleen (splenomegaly), and a decreased white blood cell count (neutropenia). Approximately 1-3% of RA patients develop Felty Syndrome. This syndrome often appears in individuals who have had RA for many years and is thought to be an outcome of prolonged inflammation.
The symptoms of Felty Syndrome can include:
Joint Pain and Swelling: Similar to RA, joint discomfort is common
Recurrent Infections: Due to neutropenia, individuals are more susceptible to infections
Enlarged Spleen: This can lead to a feeling of fullness and discomfort in the abdomen
Diagnosis of Felty Syndrome typically involves:
Medical History and Physical Examination: To identify signs of RA and spleen enlargement
Blood Tests: To check for neutropenia and other abnormalities
Imaging Tests: Such as ultrasound or CT scans to assess spleen size
Current treatments focus on managing the underlying RA and alleviating symptoms:
Disease-Modifying Antirheumatic Drugs (DMARDs): Used to control RA
Granulocyte-colony Stimulating Factor (G-CSF): To boost white blood cell production
Splenectomy (removal of the spleen) in severe cases
Researchers are currently examining the effectiveness of newer DMARDs and biological therapies in treating RA, with the hope that better RA management will reduce the incidence or severity of Felty Syndrome.
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